Increase in Nicotine Receptors Makes Quitting Harder

Research Summary

Smokers have more nicotine receptors in their brains than nonsmokers, making it more difficult for them to quit, according to researchers at Yale University.

Researchers used brain-scanning technology to compare the nicotine receptors of 16 smokers who had abstained for four days with scans from a group of 16 nonsmokers. They found that the density of common nicotine receptors was higher among smokers during early abstinence, contributing to withdrawal symptoms.

"Nicotine craving is an important factor associated with relapse," said lead author Julie Staley. "This study paves the way for determining whether medications normalize the number of receptors and why some smokers, such as women and those with neuropsychiatric disorders, have more difficulty quitting smoking."

Reference: Staley, J. K., et al. (2006) Human Tobacco Smokers in Early Abstinence Have Higher Levels of Nicotinic Acetylcholine Receptors than Nonsmokers. J. Neurosci., 26: 8707-8714.

From; Join Together Online

How to Quit Smoking Without Gaining Weight

How to Quit Smoking Without Gaining Weight


Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s